Research Journal of Pharmacognosy and Phytochemistry

M. K. Senghani ¹, P. M. Patel ², G. Vidya Sagar ³

Affiliations
1 Gayatree Automobiles, N/R Jalaram Garage, Vrundavan Park, Mandvi Bhuj Highway, Mandvi, Kutch, 370465 Gujarat, IN
2 Department of Pharmaceutical Analysis, Shree B.M Shah College of Pharmaceutical Education & Research, Modasa, Gujarat, 383315, IN
3 Veerayatan Institute of Pharmacy, Jakhania, Bhuj- Mandvi Road, Mandvi, Kutch Gujarat, 370460, IN

Abstract

Aim of the study: Epilepsy the most serious brain disorder is characterized by recurrence of seizures. So, the present study was carried out on rats and mice to evaluate the anticonvulsant activity of boswellic acids (BA) isolated from oleo-gum resin of Boswellia serrata Roxb (Burseraceae).

Materials and Methods: Three different doses of BA viz., 50, 100 and 200 mg/kg, were studied against the maximal electroshock seizure (MES) and picrotoxin (PCT)-induced convulsions. Phenytoin sodium (PS) and diazepam (DZ) were used as reference standard in MES-induced convulsion model and PCT-induced convulsions respectively.

Results: Results of the present study revealed that BA showed dosedependent anticonvulsant activity by significantly decreasing the duration of hind limb tonic extension (HLTE) and by increasing the latency of HLTE as compared to control (p<0.001) in MES model. The BA did not show any significant anticonvulsant activity in PCT-induced convulsion model.

Conclusion: From the present study, it is concluded that the BA possesses anticonvulsant activity against electrically induced convulsions in experimental animals, which supports the ethno medicinal claim of the plant in the management of epilepsy.

Keywords

Boswellic Acids, Anticonvulsant Activity, Boswellia serrata, Maximal Electroshock, Picrotoxin.

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G. Jadhav Anil ¹, B. Patil Mrutyunjay ¹, B. Narkhede Sachin ², G. Vidya Sagar ³

Affiliations
1 KLES College of Pharmacy, Belgaum, Karnataka, IN
2 Smt.BNB Swaminarayan Pharmacy College, Salvav (Vapi), IN
3 Dean, Veerayatan Institute of Pharmacy, kutch-370 460, Gujaratii, IN

Abstract

In recent times lot of interest has been generated to find out a natural remedy for hepatic disorders caused by toxins like alcohol and hepatitis virus. The present study is designed and investigate the hepatoprotective activity of Oxalis corniculata leaves against carbon tetrachloride (CCl₄) induced hepatotoxicity in female Albino Wistar rats. Forty two Albino Wistar female rats were divided in to seven equal groups each containing six animals. Four groups received the extracts of Oxalis corniculata leaves and intraperitoneal (i.p.) CCl₄ (2 ml/kg) with administration of extracts. One group was control, one treated with CCl₄ and one with normal saline. The hepatotoxicity was assessing by plasma concentration of serum bilirubin and enzymes activities. The aqueous extract (500mg/kg b.w) of Oxalis corniculata significantly reduced carbon tetrachloride induce damages in the liver which is measured by SGOT, SGPT, SALP and serum bilirubin levels in blood. The attempt has been made to extract the active constituent and identified by phytochemical investigation and hepatoprotective activity of leaves of Oxalis corniculata.

Keywords

Oxalis corniculata, Carbon Tetrachloride, Hepatoprotective.

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